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Trends Biotechnol. 2014 Aug;32(8):414-21. doi: 10.1016/j.tibtech.2014.06.002. Epub 2014 Jul 3.

Optoelectrical microfluidics as a promising tool in biology.

Author information

  • 1Birck Nanotechnology Center, School of Mechanical Engineering, Purdue University, West Lafayette, IN 47907, USA.
  • 2Birck Nanotechnology Center, School of Mechanical Engineering, Purdue University, West Lafayette, IN 47907, USA. Electronic address: wereley@purdue.edu.

Abstract

Noncontact robotic particle grippers with trapping, manipulation, and release functions are highly desired in cell biology and microfluidics. Optoelectric techniques combine optical and electrokinetic effects to create thousands of such individually addressable traps. By projecting reconfigurable light patterns, these techniques can concentrate molecules, as well as manipulate, sort, and electroporate cells in a programmable manner. We describe the underlying physical mechanisms and discuss applications in biology and future prospects of these devices.

Copyright © 2014 Elsevier Ltd. All rights reserved.

KEYWORDS:

cell manipulation; electrokinetics; microfluidics; optical tweezers; optofluidics; patterning

PMID:
24998518
[PubMed - indexed for MEDLINE]
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