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Curr Opin Cell Biol. 2014 Oct;30:51-9. doi: 10.1016/ Epub 2014 Jul 3.

Neighborly relations during collective migration.

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  • 1Institut Pasteur - CNRS URA 2582, Cell Polarity, Migration and Cancer Unit, 25 rue du Dr Roux, 75724 Paris Cedex 15, France. Electronic address:


The collective migration of sheets, cohorts, chains or streams of cells contributes to embryogenesis, tissue remodeling and repair as well as to cancer invasion. The functional coordination between neighboring cells is at the heart of collective migration, during which cells migrate with a similar speed in an identical direction. Far from being the result of the simultaneous migration of isolated cells, collective migration relies on the intercellular communication between migrating cells. Although the mechanisms of cell coordination are far from being completely understood, accumulated evidence show that exchange of mechanical and chemical information by direct intercellular contacts and by soluble extracellular signals orchestrate the coordinated behavior of collectively migrating cells.

Copyright © 2014 Elsevier Ltd. All rights reserved.

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