Abstract
A single oral dose of tetracycline deposits in bone and is readily identified with fluorescence microscopy. Two such time-spaced labels can be used to determine bone dynamic features. This is as accurate as conventional three-day labeling periods. The simplicity, improved compliance, and substantial reduction in time it takes to prepare a patient for bone biopsy all appear to be advantageous when compared with current recommendations.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Adult
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Bone Diseases, Metabolic / pathology
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Bone and Bones / anatomy & histology
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Bone and Bones / pathology*
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Demeclocycline* / administration & dosage
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Drug Administration Schedule
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Growth Plate / pathology
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Humans
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Microscopy, Fluorescence
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Middle Aged
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Tetracycline* / administration & dosage
Substances
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Demeclocycline
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Tetracycline