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Biomarkers. 2014 Sep;19(6):471-80. doi: 10.3109/1354750X.2014.937361. Epub 2014 Jul 2.

Oxidative balance score and oxidative stress biomarkers in a study of Whites, African Americans, and African immigrants.

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  • 1Department of Nutrition, Emory University , Atlanta, GA , USA .

Abstract

CONTEXT:

Oxidative balance score (OBS) is a composite measure of multiple pro- and antioxidant exposures.

OBJECTIVE:

To investigate associations of OBS with F2-isoprostanes (FIP), mitochondrial DNA copy number (mtDNA), and fluorescent oxidative products (FOP), and assess inter-relationships among the biomarkers.

METHODS:

In a cross-sectional study, associations of a thirteen-component OBS with biomarker levels were assessed using multivariable regression models.

RESULTS:

Association of OBS with FIP, but not with FOP, was in the hypothesized direction. The results for mtDNA were unstable and analysis-dependent. The three biomarkers were not inter-correlated.

CONCLUSIONS:

Different biomarkers of oxidative stress may reflect different biological processes.

KEYWORDS:

Oxidative balance; oxidative stress; race

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