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Anticancer Res. 2014 Jul;34(7):3623-8.

Use of pre-treatment 18F-FAMT PET to predict patient survival in squamous cell carcinoma of the esophagus treated by curative surgery.

Author information

  • 1Depertment of General Surgical Science, Gunma University Graduate School of Medicine, Maebashi, Japan msohda@med.gunma-u.ac.jp.
  • 2Depertment of General Surgical Science, Gunma University Graduate School of Medicine, Maebashi, Japan.
  • 3Depertment of Diagnostic Radiology and Nuclear Medicine, Gunma University Graduate School of Medicine, Maebashi, Japan.

Abstract

BACKGROUND:

[18F]-3-fluoro-alpha-methyl tyrosine (18F-FAMT) as an amino acid tracer in positron emission tomography (PET) has been widely investigated in several tumor types. Herein we investigated the clinical significance of 18F-FAMT PET uptake as a prognostic marker together in our updated data of patients with esophageal cancer.

PATIENTS AND METHODS:

We retrospectively assessed the treatment outcomes of 42 patients with histologically-confirmed esophageal cancer. The survival rate was analyzed using the median peak standardized uptake value (SUV) with 2.2 as the cut-off value.

RESULTS:

FAMT uptakes were significantly correlated with factors reflecting tumor progression. Moreover, a significant correlation was observed between FAMT uptake and disease-free survival (p=0.023). Moreover, on evaluation of individual lymph node groups, the specificity and positive predictive value were significantly higher for 18F-FAMT-PET than for 18F-FDG-PET and computed tomography (CT).

CONCLUSION:

18F-FAMT is an important pre-treatment diagnostic modality and its accumulation is a good predictor of disease-free survival (DFS) in patients with operable esophageal cancer.

Copyright© 2014 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved.

KEYWORDS:

18F-FAMT PET; 18F-FDG-PET; specificity; survival

PMID:
24982378
[PubMed - indexed for MEDLINE]
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