Drying methods for protein pharmaceuticals

Morten Jonas Maltesen; Marco van de Weert

doi:10.1016/j.ddtec.2008.11.001

Drying methods for protein pharmaceuticals

Drug Discov Today Technol. 2008 Autumn;5(2-3):e81-8. doi: 10.1016/j.ddtec.2008.11.001.

Authors

Morten Jonas Maltesen¹, Marco van de Weert²

Affiliations

¹ Department of Pharmaceutics and Analytical Chemistry, Faculty of Pharmaceutical Sciences, University of Copenhagen, Copenhagen, Denmark. Electronic address:mjm@farma.ku.dk.
² Department of Pharmaceutics and Analytical Chemistry, Faculty of Pharmaceutical Sciences, University of Copenhagen, Copenhagen, Denmark.

PMID: 24981095
DOI: 10.1016/j.ddtec.2008.11.001

Abstract

Removal of water is a common method to prolong the storage stability of protein formulations. Traditionally, freeze-drying has been the method of choice, but spray drying and supercritical drying have gained increased interest in the past decade. The proper choice of drying technology has a significant impact on the final pharmaceutical product and on the overall economy of the process.: