JAMA. 1978 Oct 27;240(18):1963-5.

Staphylococcus aureus endocarditis. Combined therapy with vancomycin and rifampin.

Faville RJ Jr, Zaske DE, Kaplan EL, Crossley K, Sabath LD, Quie PG.

Abstract

Two children with persistent bacteremia and endocarditis due to Staphylococcus aureus failed to respond to vancomycin therapy, even though serum levels greatly exceeded the inhibitory concentrations. The Staphylococcus from one patient was resistant to methicillin; the other patient had a penicillin hypersensitivity. There was a wide disparity between the minimum inhibitory and the minimum bactericidal concentrations of vancomycin. Striking clinical and laboratory evidence of improvement was demonstrated with the addition of rifampin therapy.

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Staphylococcus aureus endocarditis. Combined therapy with vancomycin and rifampin.

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