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Nutrition. 2014 Oct;30(10):1210-2. doi: 10.1016/j.nut.2014.02.029. Epub 2014 Mar 14.

Pomegranate extract exhibits in vitro activity against Clostridium difficile.

Author information

  • 1Infectious Diseases Section, VA Medical Center West Los Angeles, Los Angeles, California, USA; Research Service, VA Medical Center West Los Angeles, Los Angeles, California, USA; Department of Microbiology, Immunology and Molecular Genetics, UCLA School of Medicine, Los Angeles, California, USA; Department of Medicine, UCLA School of Medicine, Los Angeles, California, USA. Electronic address: sidfinegold@gmail.com.
  • 2Research Service, VA Medical Center West Los Angeles, Los Angeles, California, USA.
  • 3UCLA Center for Human Nutrition, UCLA School of Medicine, Los Angeles, California, USA.
  • 4Research Service, VA Medical Center West Los Angeles, Los Angeles, California, USA; Department of Microbiology, Immunology and Molecular Genetics, UCLA School of Medicine, Los Angeles, California, USA; UCLA Center for Human Nutrition, UCLA School of Medicine, Los Angeles, California, USA.

Abstract

OBJECTIVE:

To determine the possible utility of pomegranate extract in the management or prevention of Clostridium difficile infections or colonization.

METHOD:

The activity of pomegranate was tested against 29 clinical C. difficile isolates using the Clinical and Laboratory Standards Institute-approved agar dilution technique. Total phenolics content of the pomegranate extract was determined by Folin-Ciocalteau colorimetric method and final concentrations of 6.25 to 400 μg/mL gallic acid equivalent were achieved in the agar.

RESULTS:

All strains had MICs at 12.5 to 25 mg/mL gallic acid equivalent range. Our results suggest antimicrobial in vitro activity for pomegranate extract against toxigenic C. difficile.

CONCLUSION:

Pomegranate extract may be a useful contributor to the management and prevention of C. difficile disease or colonization.

Copyright © 2014 Elsevier Inc. All rights reserved.

KEYWORDS:

Clostridum difficile; MIC; Minimum inhibitory concentration; Pomegranate; Pomegranate extract; Susceptibility

[PubMed - indexed for MEDLINE]
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