Display Settings:


Send to:

Choose Destination
See comment in PubMed Commons below
Diagn Cytopathol. 2014 Jun 27. doi: 10.1002/dc.23197. [Epub ahead of print]

Fine needle aspiration of breast masses in pregnant and lactating women: Experience with 28 cases emphasizing Thinprep findings.

Author information

  • 1Department of Pathology and Cell Biology, New York Presbyterian Hospital, College of Physicians & Surgeons, Columbia University, New York, New York.



Fine needle aspiration (FNA) of breast masses in pregnant or lactating women is an uncommon procedure, and cytological interpretation is considered problematic due to atypia inherent to secretory change in glandular epithelia. Previous descriptions of "lactating adenoma" (LAd), the most common tumor in this population, have been on direct smears (DS), while ThinPrep (TP, Hologic, Boxborough, MA) findings therein remain largely uncharacterized.


FNA cases from breast masses in pregnant or lactating women (2005-2012), processed as TP and/or DS were retrospectively reviewed.


28 cases from as many patients (mean age 36 years), at 23 weeks of pregnancy to 10 months postpartum, were reviewed. Size of mass ranged from 1.0 to 4.5 cm. Corresponding histopathology was available in 21/28 cases. TP was available in 24/28 cases. Relative to DS, in TP, LAd showed "lacy" fragments, tissue paper-like texture, and globular clumps of "milky" background material, with embedded singly dispersed "bare" epithelial cell nuclei containing cherry-red macronucleoli. Architecture appeared disrupted in TP with isolated cells, smaller cell clusters, and lobules in LAd. Cellular morphology was better preserved in TP. Cytological features of carcinoma on TP were similar to DS. There were no false-positive cases. In this series, LAd was the most common diagnosis for breast masses in pregnant and lactating women (78.5%) and demonstrated background, architectural, and cellular alterations on TP.


In this setting, malignancy is an important consideration (encountered in 3/28, 11% of cases, including one false-negative angiosarcoma case). Diagn. Cytopathol. 2014. © 2014 Wiley Periodicals, Inc.

Copyright © 2014 Wiley Periodicals, Inc.


breast; fine needle aspiration cytology; lactating adenoma; liquid-based cytology; pregnancy

[PubMed - as supplied by publisher]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for John Wiley & Sons, Inc.
    Loading ...
    Write to the Help Desk