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Heart Fail Clin. 2014 Jul;10(3):471-9. doi: 10.1016/j.hfc.2014.04.005.

Novel biomarkers in heart failure with preserved ejection fraction.

Author information

  • 1Department of Internal Medicine, University of California, San Diego, 402 Dickinson Street, Suite 380, San Diego, CA 92103-8425, USA.
  • 2Cardiology Section (9111-A), VA San Diego Healthcare System, 3350 La Jolla Village Drive, San Diego, CA 92161, USA. Electronic address:


Heart failure with preserved ejection fraction (HFPEF) is a common subtype of heart failure with morbidity and mortality similar to that of heart failure with systolic dysfunction. This article discusses the numerous biomarkers that promise to play a substantial role in terms of our ability to understand the mechanisms of HFPEF and discern possible phenotypes that respond to targeted therapies: natriuretic peptides, high-sensitivity troponins, galectin-3, soluble ST2, neutrophil gelatinase-associated lipocalin, and cystatin C.

Published by Elsevier Inc.


Biomarkers; Diagnosis; Heart failure; Preserved ejection fraction; Prognosis

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