Format

Send to:

Choose Destination
See comment in PubMed Commons below
Stroke. 2014 Aug;45(8):2305-10. doi: 10.1161/STROKEAHA.114.005576. Epub 2014 Jun 26.

Brachial-ankle pulse wave velocity for predicting functional outcome in acute stroke.

Author information

  • 1From the Department of Neurology, CHA Bundang Medical Center, CHA University, Seongnam, Gyeonggi-do, Korea (J.K.); Department of Neurology, Ewha Womans University, Seoul, Korea (T.-J.S.); and Departments of Neurology (J.K., E.H.K., K.J.L., D.S., H.S.N., Y.D.K., J.H.H.) and Biostatistics (H.S.L., C.M.N.), Yonsei University College of Medicine, Seoul, Korea.
  • 2From the Department of Neurology, CHA Bundang Medical Center, CHA University, Seongnam, Gyeonggi-do, Korea (J.K.); Department of Neurology, Ewha Womans University, Seoul, Korea (T.-J.S.); and Departments of Neurology (J.K., E.H.K., K.J.L., D.S., H.S.N., Y.D.K., J.H.H.) and Biostatistics (H.S.L., C.M.N.), Yonsei University College of Medicine, Seoul, Korea. jhheo@yuhs.ac.

Abstract

BACKGROUND AND PURPOSE:

We investigated whether the brachial-ankle pulse wave velocity (baPWV) has prognostic value for predicting functional outcome after acute cerebral infarction and whether the prognostic value differs between stroke subtypes.

METHODS:

We included 1091 consecutive patients with first-ever acute cerebral infarction who underwent baPWV measurements. Stroke subtypes were classified using the Trial of Org 10172 in Acute Stroke Treatment classification. Poor functional outcomes were defined as modified Rankin Scale score >2 at 3 months after stroke onset.

RESULTS:

We noted that 181 (16.59%) patients had a poor functional outcome. In multivariate logistic regression, patients in the highest tertile of baPWV (>22.25 m/s) were found to be at increased risk for poor functional outcome (adjusted odds ratio, 1.88; 95% confidence interval, 1.06-3.40) compared with those in the lowest tertile (<17.55 m/s). No significant interaction between baPWV and stroke subtype was noted. Receiver operating characteristic curve analysis indicated that the addition of baPWV to the prediction model significantly improved the discrimination ability for poor functional outcome.

CONCLUSIONS:

baPWV has an independent prognostic value for predicting functional outcome after acute cerebral infarction. The prognostic value did not differ according to the stroke subtype.

© 2014 American Heart Association, Inc.

KEYWORDS:

prognosis; pulse wave analysis; stroke

PMID:
24968933
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire
    Loading ...
    Write to the Help Desk