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Int J Clin Exp Pathol. 2014 Apr 15;7(5):2256-64. eCollection 2014.

A case of cervical cancer expressed three mRNA variant of Hyaluronan-mediated motility receptor.

Author information

  • 1Genomic Oncology Laboratory, Medical Research Unit in Oncologic Diseases, Oncology Hospital, National Medical Center Siglo XXI, IMSS México, D.F., México.
  • 2Department of Medical Genomics and Environmental Toxicology, Biomedical Research Institute, UNAM México, D.F., México ; Biochemistry Unit, National Institute of Medical Sciences and Nutrition "Salvador Zubirán" México, D.F., México.
  • 3Biochemistry Unit, National Institute of Medical Sciences and Nutrition "Salvador Zubirán" México, D.F., México.
  • 4Department of Oncology, General Hospital of México O. D México, D.F., México.
  • 5Department of Pathology, National Medical Center Siglo XXI, IMSS México, D.F., México.
  • 6Experimental Oncology Laboratory, Department of Research, National Institute of Pediatrics México, D.F., México.

Abstract

Cervical cancer is the second malignancy in Mexico, little is known about the prognostic factors associated with this disease. Several cellular components are important in their transformation and progression. Alternative mRNA splice is an important mechanism for generating protein diversity, nevertheless, in cancer unknown mRNA diversity is expressed. Hyaluronan-mediated motility receptor (HMMR, RHAMM, CD168) is a family member of proteins, hyaluronan acid dependent, and has been associated with different malignant processes such as: angiogenesis, cell invasiveness, proliferation, metastasis and poor outcome in some tumors. In the present study we identified expression of HMMR in cervical cancer by means of RT-PCR and sequencing. Our results indicate co-expression of two HMMR variants in all samples, and one case expressed three alternative HMMR splice transcripts. These results showed the heterogeneity of mRNA transcripts of HMMR that could express in cancer and the expression of HMMR could be marker of malignancy in CC.

KEYWORDS:

Cervical cancer; HMMR; alternative splicing; expression

PMID:
24966934
[PubMed - in process]
PMCID:
PMC4069874
Free PMC Article

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