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Indian J Clin Biochem. 2014 Jul;29(3):339-44. doi: 10.1007/s12291-013-0373-5. Epub 2013 Aug 31.

Correlation of serum homocysteine levels with the severity of coronary artery disease.

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  • 1Department of Biochemistry, Kasturba Medical College, Manipal University, Manipal, India.
  • 2Department of Applied Nutrition, Dietics Welcome Group School of Hotel Management, Manipal University, Manipal, India.
  • 3Department of Cardiology, Kasturba Medical College, Manipal University, Manipal, India.


Coronary artery disease (CAD) has become the most common cause of mortality in the entire world. Homocysteine is implicated as an early atherosclerotic promoter. We studied the relationship between levels of serum homocysteine with severity of coronary artery disease. Total of 70 subjects who scheduled for coronary angiogram consented to participate in this study. In all the patients Gensini scoring system was used to assess the severity of CAD. Venous samples were taken from the patients in fasting state before angiography. Homocysteine levels in patients were measured by enzyme linked immunosorbant method and were compared with respective Genseni scores of participants. Fasting serum homocysteine levels in CAD patients were significantly higher than patients without coronary artery disease (p < 0.001). Also Homocyseine levels correlated significantly with increasing severity of CAD (p < 0.001). Serum homocysteine levels correlated well with the severity of CAD.


Coronary artery disease (CAD); Gensini scoring system; Homocysteine

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