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Virus Res. 2014 Aug 30;189:280-5. doi: 10.1016/j.virusres.2014.06.008. Epub 2014 Jun 21.

Gallic acid-based small-molecule inhibitors of JC and BK polyomaviral infection.

Author information

  • 1Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, RI 02912, United States.
  • 2Department of Chemistry, Dartmouth College, Hanover, NH, United States.
  • 3Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, RI 02912, United States. Electronic address: walter_atwood@brown.edu.

Abstract

JCPyV and BKPyV are common human polyomaviruses that cause lifelong asymptomatic persistent infections in their hosts. In immunosuppressed individuals, increased replication of JCPyV and BKPyV cause significant disease. JCPyV causes a fatal and rapidly progressing demyelinating disease known as progressive multifocal leukoencephalopathy. BKPyV causes hemorrhagic cystitis and polyomavirus associated nephropathy in bone marrow transplant recipients and in renal transplant recipients respectively. There are no specific anti-viral therapies to treat polyomavirus induced diseases. Based on detailed studies of the structures of these viruses bound to their receptors we screened several compounds that possessed similar chemical space as sialic acid for their ability to bind the virus. Positive hits in the assay were restricted to gallic acid based compounds that mimic the viruses known cellular glycan receptors. Pre-treatment of virions with these inhibitors reduced virus infection in cell culture and as such may form the basis for the development of virion specific antagonists to treat these infections.

Copyright © 2014 Elsevier B.V. All rights reserved.

KEYWORDS:

BKPyV; Hemorrhagic cystitis; JCPyV; Polyomavirus nephropathy; Progressive multifocal leukoencephalopathy; Virus receptors

PMID:
24960120
[PubMed - indexed for MEDLINE]
PMCID:
PMC4144447
[Available on 2015-08-30]
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