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Metabolomics. 2014;10(1):152-164. Epub 2013 Jul 18.

Associations between thyroid hormones and serum metabolite profiles in an euthyroid population.

Author information

  • 1Institute of Epidemiology I, Helmholtz Zentrum München, German Research Centre for Environmental Health (HMGU), Ingolstädter Landstraße 1, 85746 Neuherberg, Germany.
  • 2Institute of Epidemiology I, Helmholtz Zentrum München, German Research Centre for Environmental Health (HMGU), Ingolstädter Landstraße 1, 85746 Neuherberg, Germany ; Institute of Epidemiology II, Helmholtz Zentrum München, Neuherberg, Germany.
  • 3Institute of Genetic Epidemiology, Helmholtz Zentrum München, Neuherberg, Germany.
  • 4Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, Neuherberg, Germany ; Hannover Unified Biobank, Hannover Medical School, Hannover, Germany.
  • 5Institute of Epidemiology II, Helmholtz Zentrum München, Neuherberg, Germany.
  • 6Institute of Epidemiology II, Helmholtz Zentrum München, Neuherberg, Germany ; Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, Neuherberg, Germany.
  • 7Institute of Clinical Chemistry and Laboratory Medicine, Ernst-Moritz-Arndt-University Greifswald, Greifswald, Germany.
  • 8Institute of Bioinformatics and Systems Biology, Helmholtz Zentrum München, Neuherberg, Germany.
  • 9Institute of Bioinformatics and Systems Biology, Helmholtz Zentrum München, Neuherberg, Germany ; Department of Physiology and Biophysics, Weill Cornell Medical College, Education City, Doha, Qatar.
  • 10Institute of Experimental Genetics, Genome Analysis Center, Helmholtz Zentrum München, Neuherberg, Germany.
  • 11Institute of Experimental Genetics, Genome Analysis Center, Helmholtz Zentrum München, Neuherberg, Germany ; Institute of Experimental Genetics, Life and Food Science Center Weihenstephan, Technische Universität München, Freising-Weihenstephan, Germany.
  • 12Department of Internal Medicine II-Cardiology, University of Ulm, Medical Center, Ulm, Germany.
  • 13Institute for Clinical Diabetology, German Diabetes Center, Düsseldorf, Germany.
  • 14Institute of Epidemiology I, Helmholtz Zentrum München, German Research Centre for Environmental Health (HMGU), Ingolstädter Landstraße 1, 85746 Neuherberg, Germany ; Institute of Medical Informatics, Biometry and Epidemiology, Chair of Epidemiology, Ludwig-Maximilians-Universität München, Neuherberg, Germany ; Klinikum Großhadern, Munich, Germany.
  • 15Institute for Community Medicine, Ernst-Moritz-Arndt-University Greifswald, Greifswald, Germany.

Abstract

The aim was to characterise associations between circulating thyroid hormones-free thyroxine (FT4) and thyrotropin (TSH)-and the metabolite profiles in serum samples from participants of the German population-based KORA F4 study. Analyses were based on the metabolite profile of 1463 euthyroid subjects. In serum samples, obtained after overnight fasting (≥8), 151 different metabolites were quantified in a targeted approach including amino acids, acylcarnitines (ACs), and phosphatidylcholines (PCs). Associations between metabolites and thyroid hormone concentrations were analysed using adjusted linear regression models. To draw conclusions on thyroid hormone related pathways, intra-class metabolite ratios were additionally explored. We discovered 154 significant associations (Bonferroni p < 1.75 × 10-04) between FT4 and various metabolites and metabolite ratios belonging to AC and PC groups. Significant associations with TSH were lacking. High FT4 levels were associated with increased concentrations of many ACs and various sums of ACs of different chain length, and the ratio of C2 by C0. The inverse associations observed between FT4 and many serum PCs reflected the general decrease in PC concentrations. Similar results were found in subgroup analyses, e.g., in weight-stable subjects or in obese subjects. Further, results were independent of different parameters for liver or kidney function, or inflammation, which supports the notion of an independent FT4 effect. In fasting euthyroid adults, higher serum FT4 levels are associated with increased serum AC concentrations and an increased ratio of C2 by C0 which is indicative of an overall enhanced fatty acyl mitochondrial transport and β-oxidation of fatty acids.

KEYWORDS:

Epidemiology; Free thyroxine; Serum metabolites; Targeted metabolomics; Thyroid hormones; Thyrotropin

PMID:
24955082
[PubMed]
PMCID:
PMC4042025
Free PMC Article
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