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Hematol Oncol Stem Cell Ther. 2014 Sep;7(3):116-9. doi: 10.1016/j.hemonc.2014.06.001. Epub 2014 Jun 20.

Paraneoplastic neuromyelitis optica spectrum disorder associated with stomach carcinoid tumor.

Author information

  • 1Department of Neurology, King Fahad Specialist Hospital, 6830 Ammar Bin Thabit St, Al Muraikabat, Dammam 32253-3202, Saudi Arabia. Electronic address: talal563@yahoo.com.
  • 2Department of Neurology, King Fahad Specialist Hospital, 6830 Ammar Bin Thabit St, Al Muraikabat, Dammam 32253-3202, Saudi Arabia. Electronic address: Adnan.Sarawi@kfsh.med.sa.
  • 3Department of Neurology, University Medical Center, King Abdullah Medical City, 61 King Abdulaziz Avenue, Manama Alsuqayyah 328, Bahrain. Electronic address: mfalahmd@gmail.com.
  • 4King Khalid Medical City for Human Health Research, King Fahad Specialist Hospital, 6830 Ammar Bin Thabit St, Al Muraikabat, Dammam 32253-3202, Saudi Arabia.

Abstract

Neuromyelitis optica (NMO), or Devic's syndrome, is an autoimmune central nervous system demyelinating disorder primarily affecting the spinal cord and the optic nerves. It is characterized by the presence of NMO antibodies, alongside clinical and radiological findings. NMO and NMO-spectrum disorders (NMO-SD) have been reported in autoimmune disorders, and are infrequently described as a paraneoplastic syndrome with cancers of lung, breast, and carcinoid tumors of the thyroid. We report a patient who presented with severe vomiting, blurring of vision, vertigo, diplopia, left hemiparesis and hemisensory loss and ataxia. She was found to have a longitudinally-extensive demyelinating lesion extending from the medulla to the upper cervical spinal cord on MRI. Her gastric endoscopy revealed carcinoid tumor of the stomach, and classic paraneoplastic antibodies in the serum were negative. She had extremely high serum gastrin level and high titer of NMO IgG autoantibody. The patient made an excellent recovery with tumor resection and immunotherapy, with both clinical and radiological improvement. On rare instances, NMO or NMO-SD may present as a paraneoplastic neurological syndrome associated with carcinoid tumor of the stomach.

Copyright © 2014 King Faisal Specialist Hospital & Research Centre. Published by Elsevier B.V. All rights reserved.

KEYWORDS:

Autoimmune diseases; Carcinoid tumor associated with paraneoplastic; Demyelinating disease (CNS); Devic’s syndrome; Paraneoplastic syndrome

PMID:
24954081
[PubMed - in process]
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