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Toxicon. 2014 Sep;88:34-7. doi: 10.1016/j.toxicon.2014.06.008. Epub 2014 Jun 17.

Toxicity of Bothrops sp snake venoms from Ecuador and preclinical assessment of the neutralizing efficacy of a polyspecific antivenom from Costa Rica.

Author information

  • 1Instituto de Investigación en Salud Pública (INSPI), Guayaquil, Ecuador.
  • 2Instituto Clodomiro Picado, Facultad de Microbiología, Universidad de Costa Rica, San José, Costa Rica.
  • 3Instituto Clodomiro Picado, Facultad de Microbiología, Universidad de Costa Rica, San José, Costa Rica. Electronic address: guillermo.leon@ucr.ac.cr.

Abstract

The toxicological profile of the venoms of the snakes Bothrops asper and Bothrops atrox from Ecuador was investigated, together with the venom of a population of B. asper formerly classified as 'Bothrops xanthogrammus'. The three venoms exerted lethal, hemorrhagic, myotoxic, coagulant and defibrinogenating effects, in agreement with the characteristic toxicological profile of Bothrops sp venoms. A polyspecific antivenom (bothropic-crotalic-lachesic) manufactured in Costa Rica was assessed for its preclinical efficacy against the toxic activities of these Ecuadorian venoms. Antivenom was effective in the neutralization of the five activities tested in the three venoms. These observations are in agreement with previous reports on the extensive cross-reactivity and paraspecific neutralization of antivenoms manufactured in Latin America against the venoms of Bothrops sp snakes.

Copyright © 2014 Elsevier Ltd. All rights reserved.

KEYWORDS:

Antivenom; Bothrops asper; Bothrops atrox; Ecuador; Neutralization; Toxicity

PMID:
24950051
[PubMed - in process]
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