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Pathol Res Pract. 2014 Nov;210(11):770-3. doi: 10.1016/j.prp.2014.05.008. Epub 2014 May 22.

Colon cancer bears overexpression of OTUB1.

Author information

  • 1Department of Pathology, Qingdao University Medical College, China.
  • 2Department of Pathology, Qingdao Municipal Hospital, China.
  • 3Department of Pathology, The Affiliated Hospital of Medical College, Qingdao University, Qingdao, China. Electronic address: qdwangjigang@hotmail.com.
  • 4Department of Pathology, Qingdao Municipal Hospital, China. Electronic address: chenhua62@163.com.

Abstract

OBJECTIVE:

OTUB1 is a member of deubiquitinating enzymes; however, its expression and function in colon cancer are still unclear. The present study aimed at investigating the expression of OTUB1 in colon cancer and the relationship between the expression and some clinicopathologic parameters.

METHODS:

Immunohistochemistry and quantitative real-time PCR were carried out in selected colon cancer and normal mucosa tissues.

RESULTS:

The expression of OTUB1 protein in the colon cancer was significantly higher than normal mucosa, and the OTUB1 mRNA in colon cancer was also 3.15-fold higher than the normal mucosa. The higher expression of OTUB1 in colon cancer was related with tumor size, differentiation and lymph node metastasis.

CONCLUSIONS:

OTUB1 may play an important role in colon cancer development and metastasis.

Copyright © 2014 Elsevier GmbH. All rights reserved.

KEYWORDS:

Colon cancer; Immunohistochemistry; OTUB1; Quantitative real-time PCR

PMID:
24947413
[PubMed - in process]
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