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J Biol Chem. 2014 Jun 18. pii: jbc.M114.571950. [Epub ahead of print]

SUMO-Specific Protease 1 De-SUMOylates Sharp-1 and Controls Adipocyte Differentiation.

Author information

  • 1Shanghai Jiao Tong University School of Medicine, China.
  • 2Shanghai Jiao Tong University School of Medicine, China jkcheng@shsmu.edu.cn.

Abstract

Adipocyte differentiation is regulated by a transcriptional cascade, which mainly includes CCAAT/enhancer-binding protein (C/EBP) family members and the nuclear receptor peroxisome proliferator-activated receptor γ (PPARγ). Here, we show the defects in adipocyte differentiation as well as PPARγ expression in Senp1-/- MEF cells induced by adipogenic stimuli. We further determine that SENP1 is a specific de-SUMOylation protease for Sharp-1, a repressor for PPARγ transcription and adipogenesis. SENP1 enhances adipogenesis through de-SUMOylation of Sharp-1, which then releases Sharp-1 repression of PPARγ expression and adipocyte differentiation. These results reveal SENP1 as a novel regulator in adipogenesis.

Copyright © 2014, The American Society for Biochemistry and Molecular Biology.

KEYWORDS:

adipogenesis; cell differentiation; gene transcription; peroxisome proliferator-activated receptor (PPAR); sumoylation

PMID:
24942744
[PubMed - as supplied by publisher]
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