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Mem Inst Oswaldo Cruz. 2014 Jun;109(3):330-4.

Tuberculin skin test and interferon-gamma release assay values are associated with antimicrobial peptides expression in  polymorphonuclear cells during latent tuberculous infection.

Author information

  • 1Medical Research Unit of Zacatecas, Mexican Institute of Social Security, Zacatecas, Mexico.
  • 2Department of Environmental and Occupational Health, Center for Global Public Health, School of Public Health, University of Medicine and Dentistry New Jersey, Piscataway, NJ, USA.

Abstract

It has been reported that patients with progressive tuberculosis (TB) express abundant amounts of the antimicrobial peptides (AMPs) cathelicidin (LL-37) and human neutrophil peptide-1 (HNP-1) in circulating cells, whereas latent TB infected donors showed no differences when compared with purified protein derivative (PPD) and QuantiFERON®-TB Gold (QFT)-healthy individuals. The aim of this study was to determine whether LL-37 and HNP-1 production correlates with higher tuberculin skin test (TST) and QFT values in TB household contacts. Twenty-six TB household contact individuals between 26-58 years old TST and QFT positive with at last two years of latent TB infection were recruited. AMPs production by polymorphonuclear cells was determined by flow cytometry and correlation between TST and QFT values was analysed. Our results showed that there is a positive correlation between levels of HNP-1 and LL-37 production with reactivity to TST and/or QFT levels. This preliminary study suggests the potential use of the expression levels of these peptides as biomarkers for progression in latent infected individuals.

PMID:
24937049
PMCID:
PMC4131785
[PubMed - indexed for MEDLINE]
Free PMC Article
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