Mutat Res. 1989 Mar;217(2):109-15.

Expression of DNA damage-inducible genes of Escherichia coli upon treatment with methylating, ethylating and propylating agents.

Source

Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester 01655.

Abstract

Several alkylation-inducible genes have been identified by construction of Mu-d1 (Apr lac) fusions to genes whose expression is increased in response to alkylation treatment, but not UV treatment. We have examined the induction of 4 different alkylation-inducible genes by treatment with a variety of methylating and ethylating agents, and a propylating agent. We have compared the induction of the alkylation-inducible genes with the induction of the sulA gene, which is a component of the SOS response to DNA damage. We find that the Ada-regulated adaptive response genes (ada-alkB, alkA and aidB) are induced primarily in response to methylation treatment. The ada-independent aidC gene is induced upon treatment with agents that alkylate predominantly by SN1 nucleophilic attack. aidC induction occurs only when cells are not aerated during treatment. The SOS response, as indicated by sulA induction, is strongly induced by all types of alkylating agents used.

PMID:: 2493133; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances, Grant Support

Publication Types

Research Support, U.S. Gov't, P.H.S.

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Grant Support

GM37052/GM/NIGMS NIH HHS/United States

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Related citations in PubMed

Review Adaptive response of Escherichia coli to alkylation damage. [Environ Mol Mutagen. 1988]
Review Adaptive response of Escherichia coli to alkylation damage.
Volkert MR. Environ Mol Mutagen. 1988; 11(2):241-55.
Induction of the alkylation-inducible aidB gene of Escherichia coli by anaerobiosis. [J Bacteriol. 1989]
Induction of the alkylation-inducible aidB gene of Escherichia coli by anaerobiosis.
Volkert MR, Hajec LI, Nguyen DC. J Bacteriol. 1989 Feb; 171(2):1196-8.
Induction of the alkylation-inducible aidB gene of Escherichia coli by cytoplasmic acidification and N-ethylmaleimide. [Mutat Res. 1994]
Induction of the alkylation-inducible aidB gene of Escherichia coli by cytoplasmic acidification and N-ethylmaleimide.
Smirnova GV, Oktyabrsky ON, Moshonkina EV, Zakirova NV. Mutat Res. 1994 Jan; 314(1):51-6.
Induction of specific Escherichia coli genes by sublethal treatments with alkylating agents. [Proc Natl Acad Sci U S A. 1984]
Induction of specific Escherichia coli genes by sublethal treatments with alkylating agents.
Volkert MR, Nguyen DC. Proc Natl Acad Sci U S A. 1984 Jul; 81(13):4110-4.
Review Molecular mechanisms of adaptive response to alkylating agents in Escherichia coli and some remarks on O(6)-methylguanine DNA-methyltransferase in other organisms. [Mutat Res. 2002]
Review Molecular mechanisms of adaptive response to alkylating agents in Escherichia coli and some remarks on O(6)-methylguanine DNA-methyltransferase in other organisms.
Kleibl K. Mutat Res. 2002 Sep; 512(1):67-84.

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Cited by 4 PubMed Central articles

Gene expression profiling of Corynebacterium glutamicum during Anaerobic nitrate respiration: induction of the SOS response for cell survival. [J Bacteriol. 2011]
Gene expression profiling of Corynebacterium glutamicum during Anaerobic nitrate respiration: induction of the SOS response for cell survival.
Nishimura T, Teramoto H, Inui M, Yukawa H. J Bacteriol. 2011 Mar; 193(6):1327-33. Epub 2011 Jan 14.
Selective degradation of reverse gyrase and DNA fragmentation induced by alkylating agent in the archaeon Sulfolobus solfataricus. [Nucleic Acids Res. 2006]
Selective degradation of reverse gyrase and DNA fragmentation induced by alkylating agent in the archaeon Sulfolobus solfataricus.
Valenti A, Napoli A, Ferrara MC, Nadal M, Rossi M, Ciaramella M. Nucleic Acids Res. 2006; 34(7):2098-108. Epub 2006 Apr 14.
The AidB component of the Escherichia coli adaptive response to alkylating agents is a flavin-containing, DNA-binding protein. [J Bacteriol. 2006]
The AidB component of the Escherichia coli adaptive response to alkylating agents is a flavin-containing, DNA-binding protein.
Rohankhedkar MS, Mulrooney SB, Wedemeyer WJ, Hausinger RP. J Bacteriol. 2006 Jan; 188(1):223-30.

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