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Clin Res Hepatol Gastroenterol. 2014 Dec;38(6):699-705. doi: 10.1016/j.clinre.2014.04.015. Epub 2014 Jun 9.

Expression of epithelial cell adhesion molecule associated with elevated ductular reactions in hepatocellar carcinoma.

Author information

  • 1Department of General Surgery, the Suzhou Hospital Affiliated to Nanjing Medical University, Suzhou 215001, China; Tumor Immunology and Gene Therapy Center, Eastern Hepatobiliary Surgery Hospital, the Second Military Medical University, Shanghai 200438, China.
  • 2Tumor Immunology and Gene Therapy Center, Eastern Hepatobiliary Surgery Hospital, the Second Military Medical University, Shanghai 200438, China; Department of Gastrointestinal surgery, the Third Affiliated Hospital of Soochow University, Changzhou 213003, China.
  • 3Department of Special Treatment and Liver Transplantation, Eastern Hepatobiliary Surgery Hospital, the Second Military Medical University, Shanghai 200438, China.
  • 4Tumor Immunology and Gene Therapy Center, Eastern Hepatobiliary Surgery Hospital, the Second Military Medical University, Shanghai 200438, China.
  • 5Department of Special Treatment and Liver Transplantation, Eastern Hepatobiliary Surgery Hospital, the Second Military Medical University, Shanghai 200438, China. Electronic address: jiameiyang@gmail.com.

Abstract

AIM:

To evaluate the prognostic significance of the epithelial cell adhesion molecule (EpCAM) expression in HCC, the relationship between EpCAM with ductular reactions and other clinical features.

METHODS:

From 2001 to 2003, 106 HCC patients who underwent curative resection in Eastern Hepatobiliary Hospital were enrolled. The expression of EpCAM in tumoral tissues and ductular reactions in paired non-tumoral tissues was assessed by immunohistochemistry. EpCAM was evaluated with prognosis, ductular reactions and other clinical variables.

RESULTS:

HCC expressing high level of EpCAM showed more aggressively than usual progressed HCC. High EpCAM expression was associated with poor overall survival and recurrence free survival. (P=0.0005, 0.0019, respectively). A close association was found between tumoral EpCAM expression and peritumoral ductular reactions. Patients with high level of ductular reactions tended to have higher EpCAM expression than those with low level (P=0.016).

CONCLUSION:

HCC stratification by EpCAM may reflect different prognosis. EpCAM expression correlated with ductular reactions may be a result of unregulated activation and differentiation blockage of progenitor cells.

Copyright © 2014 Elsevier Masson SAS. All rights reserved.

[PubMed - indexed for MEDLINE]
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