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Clin Pediatr (Phila). 1989 Feb;28(2):81-5.

Valproic acid prenatal exposure. Association with lipomyelomeningocele.

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  • 1Department of Pediatrics, University of Colorado School of Medicine, Denver.


Valproic acid is an anticonvulsant that has been associated with open neural tube defects. We report a family in which the maternal use of valproic acid, and other anticonvulsants, during pregnancy resulted in different malformations in two siblings, one of which had a lipomyelomeningocele. The association of valproic acid and closed neural tube defects has not previously been reported. A brief review of the teratogenic effects of valproic acid is included as well as the implications for early surgical management of lipomyelomeningocele.

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