Format

Send to:

Choose Destination
See comment in PubMed Commons below
Anticancer Res. 2014 Jun;34(6):2991-6.

Insulin-like growth factor receptor 1 mRNA expression as a prognostic marker in advanced non-small cell lung cancer.

Author information

  • 1Department of Oncology, Finsen Centre, National University Hospital, Copenhagen, Denmark Laboratory of Pharmacogenomics, Division of Oncology, Center for Applied Medical Research, University of Navarra, Pamplona, Spain adamvilmar@hotmail.com.
  • 2Department of Pathology, Diagnostic Centre, National University Hospital, Copenhagen, Denmark.
  • 3Laboratory of Pharmacogenomics, Division of Oncology, Center for Applied Medical Research, University of Navarra, Pamplona, Spain.
  • 4Department of Oncology, Finsen Centre, National University Hospital, Copenhagen, Denmark.

Abstract

BACKGROUND:

The insulin-like growth factor 1 receptor (IGF1R) has yet to be established as a biomarker in non-small cell lung cancer (NSCLC) but could prove useful in customized chemotherapy. We explored its prognostic value using both quantitative real-time reverse transcriptase polymerase chain reaction (qRT-PCR) and immunohistochemistry (IHC).

MATERIALS AND METHODS:

Analyses of IGF1R were performed on patients with advanced NSCLC, included in a randomized chemotherapy trial, having large, representative tissue samples. IGF1R mRNA and protein expression were correlated to clinical end-points.

RESULTS:

Surgical tissue samples were available from 33 patients deemed inoperable. IGF1R status varied according to histopathology. Patients with tumors positive for IGF1R mRNA expression had a shorter progression-free and overall survival when compared to the negative sub-group (6.1 vs. 7.4 months, p=0.039 and 10.9 vs. 14.3 months, p=0.038, respectively). IGF1R protein expression showed a similar, although non-significant tendency.

CONCLUSION:

IGF1R mRNA expression may be a prognostic biomarker in advanced NSCLC and should be investigated in a larger population.

Copyright© 2014 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved.

KEYWORDS:

Advanced NSCLC; immunohistochemical analysis; insulin-like growth factor 1 receptor; methodology; qRT-PCR

PMID:
24922664
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire
    Loading ...
    Write to the Help Desk