Format

Send to:

Choose Destination
See comment in PubMed Commons below
Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2014 May;39(5):501-10. doi: 10.3969/j.issn.1672-7347.2014.05.011.

[Evaluation of the influence of humidity and temperature on the drug stability by initial average rate experiment].

[Article in Chinese]

Author information

  • 1Department of Pharmaceutics, School of Pharmacy, Anhui University of Chinese Medicine, Hefei 230031, China hening826@163.com.

Abstract

OBJECTIVE:

To evaluate the influence of temperature and humidity on the drug stability by initial average rate experiment, and to obtained the kinetic parameters.

METHODS:

The effect of concentration error, drug degradation extent, humidity and temperature numbers, humidity and temperature range, and average humidity and temperature on the accuracy and precision of kinetic parameters in the initial average rate experiment was explored. The stability of vitamin C, as a solid state model, was investigated by an initial average rate experiment.

RESULTS:

Under the same experimental conditions, the kinetic parameters obtained from this proposed method were comparable to those from classical isothermal experiment at constant humidity. The estimates were more accurate and precise by controlling the extent of drug degradation, changing humidity and temperature range, or by setting the average temperature closer to room temperature.

CONCLUSION:

Compared with isothermal experiments at constant humidity, our proposed method saves time, labor, and materials.

PMID:
24921403
[PubMed - in process]
Free full text
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for CENTRAL SOUTH UNIVERSITY
    Loading ...
    Write to the Help Desk