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Muscle Nerve. 2014 Jun 11. doi: 10.1002/mus.24316. [Epub ahead of print]

Low-intensity running exercise enhances the capillary volume and pro-angiogenic factors in the soleus muscle of type 2 diabetic rats.

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  • 1Department of Food Sciences and Nutrition, Nagoya Women's University, Nagoya, Japan.


Introduction: This study determined the effects of low-intensity exercise on the 3-D capillary structure and associated angiogenic factors in the soleus muscle of Goto-Kakizaki (GK) diabetic rats. Methods: Four groups of male rats were studied: sedentary non-diabetic (Con), exercised non-diabetic control (Ex), sedentary GK, and exercised GK (GK+Ex). Rats in the Ex and GK+Ex groups were subjected to chronic low-intensity running on a treadmill (15 m/min, 60 min/session, 5 sessions/week for 3 weeks). Results: Although mean capillary volume and diameter were lower in the GK compared with all other groups, low-intensity exercise increased both of these measures in GK rats. Mitochondrial markers, i.e., SDH activity and PGC-1α expression, and the levels of angiogenic factors were, higher in the GK+Ex than all other groups. Exercise increased VEGF protein levels and the VEGF-to-TSP-1 ratio, an indicator of angiogenesis, in GK rats. Conclusions: Combined, the results indicate that low-intensity exercise reduces some of the microcirculatory complications in the type 2 diabetic muscles. © 2014 Wiley Periodicals, Inc.

Copyright © 2014 Wiley Periodicals, Inc., a Wiley company.


angiogenic signalings; diabetes complications; exercise; microvascular disease; muscle 3-D capillary architecture

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