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PLoS One. 2014 Jun 10;9(6):e99857. doi: 10.1371/journal.pone.0099857. eCollection 2014.

Epstein-Barr virus (EBV) infection in Chinese children: a retrospective study of age-specific prevalence.

Author information

  • 1Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, P.R. China.
  • 2Department of Medical Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences/Peking Union Medical College, Beijing, P.R. China.
  • 3Division of Infectious Diseases, Brigham and Women's Hospital, Boston, Massachusetts, United States of America; Department of Microbiology and Immunobiology, Harvard University, Boston, Massachusetts, United States of America.
  • 4Department of Otorhinolaryngology, Guangzhou Women and Children's Medical Center, Guangzhou, P.R. China.
  • 5Neonatal Intense Care Unit, Guangdong Women and Children's Hospital, Guangzhou, P.R. China.

Abstract

BACKGROUND:

Epstein-Barr Virus (EBV) is a globally prevalent herpesvirus associated with infectious mononucleosis and many malignancies. The survey on EBV prevalence appears to be important to study EBV-related diseases and determine when to administer prophylactic vaccine. The purpose of this retrospective study was to collect baseline information about the prevalence of EBV infection in Chinese children.

METHODOLOGY/PRINCIPAL FINDING:

We collected 1778 serum samples from healthy children aged 0 to 10, who were enrolled in conventional health and nutrition examinations without any EBV-related symptom in 2012 and 2013 in North China (nā€Š=ā€Š973) and South China (nā€Š=ā€Š805). We detected four EBV-specific antibodies, i.e., anti-VCA-IgG and IgM, anti-EBNA-IgG and anti-EA-IgG, by ELISA, representing all of the phases of EBV infection. The overall EBV seroprevalence in samples from North and South China were 80.78% and 79.38% respectively. The EBV seropositivity rates dropped slightly at age 2, and then increased gradually with age. The seroprevalence became stabilized at over 90% after age 8. In this study, the seroprevalence trends between North and South China showed no difference (P>0.05), and the trends of average antibody concentrations were similar as well (P>0.05).

CONCLUSIONS/SIGNIFICANCE:

EBV seroprevalence became more than 50% before age 3 in Chinese children, and exceed 90% after age 8. This study can be helpful to study the relationship between EBV and EBV-associated diseases, and supportive to EBV vaccine development and implementation.

PMID:
24914816
[PubMed - indexed for MEDLINE]
PMCID:
PMC4051769
Free PMC Article
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