Short communication: HIV-1 gag genetic variation in a single acutely infected participant defined by high-resolution deep sequencing

AIDS Res Hum Retroviruses. 2014 Aug;30(8):806-11. doi: 10.1089/AID.2014.0097. Epub 2014 Jul 23.

Abstract

Acute HIV-1 infection is characterized by the rapid generation of highly diverse genetic variants to adapt to the new host environment. Understanding the dynamics of viral genetic variation at this stage of infection is critical for vaccine design efforts and early drug treatment. Here, using a high-resolution deep sequencing approach targeting the HIV-1 gag region, we reveal very early immune pressure with dramatic subpopulation shifts in a single acutely infected participant providing further insight into the genetic dynamics of acute HIV-1 infection.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adaptation, Biological
  • Genetic Variation*
  • HIV Infections / virology*
  • HIV-1 / genetics*
  • HIV-1 / immunology
  • High-Throughput Nucleotide Sequencing*
  • Humans
  • Molecular Sequence Data
  • gag Gene Products, Human Immunodeficiency Virus / genetics*
  • gag Gene Products, Human Immunodeficiency Virus / immunology

Substances

  • gag Gene Products, Human Immunodeficiency Virus

Associated data

  • BioProject/PRJNA244693