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World J Gastroenterol. 2014 Jun 7;20(21):6594-601. doi: 10.3748/wjg.v20.i21.6594.

Inflammatory markers as selection criteria of hepatocellular carcinoma in living-donor liver transplantation.

Author information

  • Gun Hyung Na, Dong Goo Kim, Jae hyun Han, Eun Young Kim, Soo Ho Lee, Tae Ho Hong, Young Kyoung You, Department of Surgery, Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul 137-701, South Korea.

Abstract

AIM:

To investigate that inflammatory markers can predict accurately the prognosis of hepatocelluar carcinoma (HCC) patients in living-donor liver transplantation (LDLT).

METHODS:

From October 2000 to November 2011, 224 patients who underwent living donor liver transplantation for HCC at our institution were enrolled in this study. We analyzed disease-free survival (DFS) and overall survival (OS) after LT in patients with HCC and designed a new score model using pretransplant neutrophil-lymphocyte ratio (NLR) and C-reactive protein (CRP).

RESULTS:

The DFS and OS in patients with an NLR level ≥ 6.0 or CRP level ≥ 1.0 were significantly worse than those of patients with an NLR level < 6.0 or CRP level < 1.0 (P = 0.049, P = 0.003 for NLR and P = 0.010, P < 0.001 for CRP, respectively). Using a new score model using the pretransplant NLR and CRP, we can differentiate HCC patients beyond the Milan criteria with a good prognosis from those with a poor prognosis.

CONCLUSION:

Combined with the Milan criteria, new score model using NLR and CRP represent new selection criteria for LDLT candidates with HCC, especially beyond the Milan criteria.

KEYWORDS:

C-reactive protein; Hepatocellular carcinoma; Liver transplantation; Neutrophil-lymphocyte ratio; Selection criteria

PMID:
24914382
[PubMed - in process]
PMCID:
PMC4047346
Free PMC Article

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