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Psychiatry Res. 2014 Aug 30;223(2):157-63. doi: 10.1016/j.pscychresns.2014.05.006. Epub 2014 May 22.

Neural signatures of the interaction between the 5-HTTLPR genotype and stressful life events in healthy women.

Author information

  • 1Psychiatric Clinic, Department of Neurosciences, University of Padova, Via Giustiniani 3, 35128 Padova, Italy; Centro di Neuroscienze Cognitive, Universit√† di Padova, Italy. Electronic address: angela.favaro@unipd.it.
  • 2Department of Medicine and Surgery, University of Salerno, Italy; IRCCS Istituto San Camillo, Venezia, Italy.
  • 3Laboratory of Epidemiology, Neuroimaging and Telemedicine - LENITEM, IRCCS Istituto Centro San Giovanni di Dio, Fatebenefratelli, Brescia, Italy.
  • 4Clinical Genetics Unit, Department of Woman and Child Health, University of Padova, Italy.
  • 5Psychiatric Clinic, Department of Neurosciences, University of Padova, Via Giustiniani 3, 35128 Padova, Italy; Centro di Neuroscienze Cognitive, Universit√† di Padova, Italy.
  • 6Psychiatric Clinic, Department of Neurosciences, University of Padova, Via Giustiniani 3, 35128 Padova, Italy.
  • 7IRCCS Istituto San Camillo, Venezia, Italy; Memory Clinic and LANVIE - Laboratory of Neuroimaging of Aging, University Hospitals and University of Geneva, Geneva, Switzerland.

Abstract

A change in neural connectivity of brain structures implicated in the memory of negative life events has been hypothesized to explain the enhancement of memory encoding during the processing of negative stimuli in depressed patients. Here, we investigated the effects of the interaction between negative life events and the 5-HTTLPR genotype - a polymorphism of the serotonin transporter gene - on the functional and structural connectivity of the hippocampal area in 34 healthy women. All participants were genotyped for the presence of the 5-HTTLPR short variant and for the A/G single-nucleotide polymorphism; they underwent clinical assessment including structured diagnostic interviews to exclude the presence of psychiatric disorders and to assess the presence of stressful life events. Resting state functional magnetic resonance imaging and diffusion tensor imaging scans were performed. We found significant interactions between stressful events and the 5-HTTLPR genotype in both the functional connectivity of the parahippocampus with the posterior cingulate cortex and the structural connectivity between the hippocampus and both the amygdala and the putamen. In addition, we found several genotype-related differences in the relationship between functional/structural connectivity of the hippocampal area and the ability to update expectations or stress-related phenotypes, such as anxiety symptoms. If confirmed by future studies, these mechanisms may clarify the role of the 5HTTLPR genotype as a risk factor for depression, in interaction with negative events.

Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

KEYWORDS:

5-HTTLPR; Depression; Diffusion tensor imaging; Iowa Gambling Task; Memory bias; Resting state fMRI

PMID:
24914006
[PubMed - indexed for MEDLINE]
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