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Atherosclerosis. 2014 Aug;235(2):328-33. doi: 10.1016/j.atherosclerosis.2014.04.036. Epub 2014 May 22.

Circulating irisin levels are positively associated with endothelium-dependent vasodilation in newly diagnosed type 2 diabetic patients without clinical angiopathy.

Author information

  • 1Graduate School, Southern Medical University, Guangzhou Avenue North 1838, Guangzhou 510515, China; Department of Endocrinology, Wuhan General Hospital of Guangzhou Command, Wuluo Road 627, Wuhan 430070, Hubei Province, China. Electronic address: xianglin832010@hotmail.com.
  • 2Department of Endocrinology, Wuhan General Hospital of Guangzhou Command, Wuluo Road 627, Wuhan 430070, Hubei Province, China. Electronic address: Guangda64@hotmail.com.
  • 3Department of Endocrinology, Wuhan General Hospital of Guangzhou Command, Wuluo Road 627, Wuhan 430070, Hubei Province, China. Electronic address: Yueling1@medmail.com.cn.
  • 4Department of Endocrinology, Wuhan General Hospital of Guangzhou Command, Wuluo Road 627, Wuhan 430070, Hubei Province, China. Electronic address: Zhangjx666@gmail.com.
  • 5Department of Endocrinology, Wuhan General Hospital of Guangzhou Command, Wuluo Road 627, Wuhan 430070, Hubei Province, China. Electronic address: ZLS7111@yahoo.com.cn.

Abstract

OBJECTIVE:

Irisin is a newly identified myokine that can promote energy expenditure and alleviate insulin-resistance in animal model. It has been established that insulin resistance is frequently associated with endothelial dysfunction. Therefore, we hypothesize that circulating irisin levels are associated with endothelial dysfunction in type 2 diabetes.

METHODS:

One hundred and eighty eight patients with newly diagnosed type 2 diabetes and 40 healthy subjects were recruited. Serum irisin concentrations were measured by using enzyme-linked immunosorbent assay, and flow-mediated dilation (FMD) was evaluated by using high-resolution ultrasound.

RESULTS:

The mean value of circulating irisin levels in newly diagnosed type 2 diabetes was 13.25 ng/ml, which was significantly lower than that in controls (25.98 ng/ml, p < 0.001). By dividing the distribution of FMD levels into quartiles, serum irisin levels were increased gradually with the increase of FMD levels (p < 0.001). Multivariate stepwise regression analysis demonstrated that serum irisin levels were independently associated with FMD (p = 0.009). By logistic regression analysis the odds ratio for lower FMD levels was reduced by 11.8% per 1 ng/ml increase in serum irisin concentration after adjustment for multivariate metabolic factors [OR (95% CI); 0.882 (0.709-0.969)].

CONCLUSION:

These results demonstrated that circulating irisin levels were decreased in newly diagnosed Chinese type 2 diabetic patients without clinical angiopathy and positively associated with FMD levels.

Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

KEYWORDS:

Circulating irisin; Endothelial dysfunction; Type 2 diabetes

PMID:
24911636
[PubMed - in process]
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