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Pharmacol Rep. 2014 Apr;66(2):235-8. doi: 10.1016/j.pharep.2013.09.004. Epub 2014 Mar 2.

ABCB1 C3435T polymorphism is associated with susceptibility to major depression, but not with a clinical response to citalopram in a Turkish population.

Author information

  • 1Akdeniz University, Medical Faculty, Department of Pharmacology, Antalya, Turkey. Electronic address:
  • 2Ministry of Health of Turkey, General Directorate of Pharmaceuticals and Pharmacy, Clinical Drug Trials Department, Ankara, Turkey.
  • 3Gaziosmanpasa University Medical Faculty, Department of Psychiatry, Tokat, Turkey.
  • 4Gazi University Medical Faculty, Department of Genetics, Ankara, Turkey.
  • 5Erenkoy Psychiatry and Neurology Education and Research Hospital, Department of Psychiatry, Istanbul, Turkey.
  • 6Bal?kesir State Hospital, Department of Psychiatry, Bal?kesir, Turkey.
  • 7Department of Research and Development, Division of Psychiatry, St Olavs University Hospital, Trondheim, Norway; Department of Neuroscience, Faculty of Medicine, Norwegian University of Science and Technology, Norway.
  • 8Gazi University Medical Faculty, Department of Pharmacology, Ankara, Turkey.



The ATP-binding cassette sub-family B member 1 (ABCB1) gene, which encodes the p-glycoprotein at the blood-brain barrier, is investigated for patients' susceptibility to major depressive disorder (MDD) and their therapeutic response to antidepressants. However, there is an inconsistency between the studies of different ethnic groups. The current study aimed to determine the potential correlations of the ABCB1 gene C3435T polymorphism with the susceptibility to MDD and the therapeutic response to citalopram in a Turkish population.


Fifty-four patients with MDD who received citalopram and 70 controls from the Turkish population were genotyped for ABCB1 C3435T polymorphism. To assess the therapeutic response to citalopram, all patients were rated baseline, first, second, fourth and sixth weeks according to the 17-item Hamilton Rating Scale for Depression (HAMD-17).


There was a significant correlation between the patient and control groups for ABCB1 C3435T polymorphism. Distribution of CC genotype and C allele frequency were higher in the patients than in the control group (p = 0.006, p = 0.020, respectively). However, no correlation between ABCB1 C3435T polymorphism and a therapeutic response to citalopram was observed.


Our results suggested that C3435T polymorphism in the ABCB1 gene may be an indicator of the susceptibility to major depression, without a likely treatment response to citalopram in a Turkish population. These findings should be replicated in studies on larger patient groups with different ethnicities.

Copyright © 2014 Institute of Pharmacology, Polish Academy of Sciences. Published by Elsevier Urban & Partner Sp. z o.o. All rights reserved.


ABCB1; Citalopram; Depression; Polymorphism; Response

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