Abstract
The efficacy of Malarone(®) alone and in combination with doxycycline (DOXY) against Babesia gibsoni infections was examined in 8 dogs. In all dogs except one treated with Malarone(®), parasitemia decreased, and anemia improved soon after initiation of treatment. However, 3 of 4 dogs treated with Malarone(®) relapsed, and relapse was inhibited in 2 of 4 dogs treated with Malarone(®) and DOXY. All relapsed dogs responded well to the second treatment, but 1 dog relapsed again and did not respond to the third treatment. Malarone(®) may be useful for acute stage of B. gibsoni infections, and at least second repeating treatment might be effective.
MeSH terms
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Alanine Transaminase / blood
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Alkaline Phosphatase / blood
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Animals
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Atovaquone / administration & dosage
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Atovaquone / pharmacology*
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Atovaquone / therapeutic use
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Babesia / growth & development*
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Babesiosis / drug therapy
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Babesiosis / parasitology*
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Bilirubin / analysis
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Blood Cell Count / veterinary
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Blood Urea Nitrogen
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Creatinine / blood
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DNA, Protozoan / chemistry
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DNA, Protozoan / genetics
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Dog Diseases / drug therapy
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Dog Diseases / parasitology*
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Dogs
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Doxycycline / administration & dosage
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Doxycycline / pharmacology*
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Doxycycline / therapeutic use
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Drug Combinations
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Drug Therapy, Combination / veterinary
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Female
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Globulins / analysis
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Male
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Parasitemia / drug therapy
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Parasitemia / parasitology
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Parasitemia / veterinary*
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Polymerase Chain Reaction / veterinary
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Proguanil / administration & dosage
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Proguanil / pharmacology*
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Proguanil / therapeutic use
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Serum Albumin / analysis
Substances
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DNA, Protozoan
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Drug Combinations
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Globulins
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Serum Albumin
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atovaquone, proguanil drug combination
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Creatinine
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Alanine Transaminase
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Alkaline Phosphatase
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Doxycycline
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Bilirubin
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Proguanil
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Atovaquone