Format

Send to:

Choose Destination
See comment in PubMed Commons below
Am J Physiol Heart Circ Physiol. 2014 Aug 1;307(3):H284-91. doi: 10.1152/ajpheart.00305.2014. Epub 2014 Jun 6.

And the beat goes on: maintained cardiovascular function during aging in the longest-lived rodent, the naked mole-rat.

Author information

  • 1Department of Physiology and the Sam and Ann Barshop Institute for Aging and Longevity Studies, The University of Texas Health Science Center at San Antonio, San Antonio, Texas;
  • 2Section of Cardiovascular Research, Department of Medicine, Baylor College of Medicine, Houston, Texas; Indus Instruments, Webster, Texas;
  • 3Mississippi Center for Heart Research, Department of Physiology and Biophysics, University of Mississippi Medical Center and Research Service, G.V. (Sonny) Montgomery Veterans Affairs Medical Center, Jackson, Mississippi.
  • 4Department of Physiology and the Sam and Ann Barshop Institute for Aging and Longevity Studies, The University of Texas Health Science Center at San Antonio, San Antonio, Texas; Buffenstein@UTHSCSA.edu.

Abstract

The naked mole-rat (NMR) is the longest-lived rodent known, with a maximum lifespan potential (MLSP) of >31 years. Despite such extreme longevity, these animals display attenuation of many age-associated diseases and functional changes until the last quartile of their MLSP. We questioned if such abilities would extend to cardiovascular function and structure in this species. To test this, we assessed cardiac functional reserve, ventricular morphology, and arterial stiffening in NMRs ranging from 2 to 24 years of age. Dobutamine echocardiography (3 μg/g ip) revealed no age-associated changes in left ventricular (LV) function either at baseline or with exercise-like stress. Baseline and dobutamine-induced LV pressure parameters also did not change. Thus the NMR, unlike other mammals, maintains cardiac reserve with age. NMRs showed no cardiac hypertrophy, evidenced by no increase in cardiomyocyte cross-sectional area or LV dimensions with age. Age-associated arterial stiffening does not occur since there are no changes in aortic blood pressures or pulse-wave velocity. Only LV interstitial collagen deposition increased 2.5-fold from young to old NMRs (P < 0.01). However, its effect on LV diastolic function is likely minor since NMRs experience attenuated age-related increases in diastolic dysfunction in comparison with other species. Overall, these findings conform to the negligible senescence phenotype, as NMRs largely stave off cardiovascular changes for at least 75% of their MLSP. This suggests that using a comparative strategy to find factors that change with age in other mammals but not NMRs could provide novel targets to slow or prevent cardiovascular aging in humans.

KEYWORDS:

arterial stiffness; cardiac reserve; cardiovascular aging; naked mole-rat; negligible senescence

PMID:
24906918
[PubMed - indexed for MEDLINE]
PMCID:
PMC4121653
[Available on 2015-08-01]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire
    Loading ...
    Write to the Help Desk