As the focus on modern neurosurgery has shifted to the realm of technological advancement, some patients and their loved ones still hold a strong faith in their religion to guide them through the process. This study aimed to determine whether religion as a coping mechanism was beneficial for patients before, during and after craniotomy. Qualitative case study methodology was used. Interviews were conducted with randomly selected 36 adult patients who underwent surgery for a benign or malignant brain tumour. Interviews were audio recorded and transcribed, and the data subjected to thematic analysis. Four overarching themes emerged from the data: (1) religion significantly benefited neurosurgical patients; (2) neurosurgical patients did not require a dedicated religious room in the hospital; (3) neurosurgical patients required religious resources such as leaders and/or groups; and (4) patients were not in favour of their physician engaging in the religious ritual. Most patients found religion to be an effective coping mechanism, offering them strength, comfort, and hope through the surgery. The findings from this study emphasize the need for including a "religious time-out" before and after surgery and the inclusion of religious leaders/groups for those in favour to ensure quality care and patient satisfaction.