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BMC Microbiol. 2014 Jun 7;14:148. doi: 10.1186/1471-2180-14-148.

Identification of a New Delhi metallo-β-lactamase-4 (NDM-4)-producing Escherichia coli in Italy.

Author information

  • 1Microbiology Unit DISC, University of Genoa, IRCCS AOU San Martino-IST, Largo R, Benzi 10, 16132 Genoa, Italy. anna.marchese@unige.it.

Abstract

BACKGROUND:

During June-July 2012, six imipenem-resistant Escherichia coli isolates were isolated from two patients hospitalized in a ward of one large tertiary-care hospital in Genoa, Italy. Genetic features associated with blaNDM-4 gene were investigated.

RESULTS:

The isolates exhibited the same PFGE profile and a multidrug-resistant (MDR) phenotype to aminoglycosides, fluoroquinolones, and β-lactams. The strains produced the NDM-4 carbapenemase and the blaNDM-4 gene was part of the variable region of a class 1 integron. MLST analysis revealed that all isolates belonged to sequence type 405 (ST405).

CONCLUSIONS:

This is the first report on the emergence of an MDR strain of E.coli producing the NDM-4 MBL in Italy.

PMID:
24906230
[PubMed - indexed for MEDLINE]
PMCID:
PMC4060580
Free PMC Article
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