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Cell. 2014 Jun 5;157(6):1251-2. doi: 10.1016/j.cell.2014.05.023.

Delivering three punches to knockout intracellular bacteria.

Author information

  • 1Centre d'Immunologie de Marseille-Luminy, UM2 Aix-Marseille Université, 13288 Marseille, France; INSERM U1104, 13288 Marseille, France; CNRS UMR7280, 13288 Marseille, France.
  • 2Centre d'Immunologie de Marseille-Luminy, UM2 Aix-Marseille Université, 13288 Marseille, France; INSERM U1104, 13288 Marseille, France; CNRS UMR7280, 13288 Marseille, France; Service d'Immunologie, Assistance Publique-Hôpitaux de Marseille, Hôpital de la Conception, 13285 Marseille, France. Electronic address: vivier@ciml.univ-mrs.fr.

Abstract

Cytotoxic lymphocytes kill bacteria-infected cells, but the mechanisms at work remain unclear. Walch et al. show that these lymphocytes deliver a toxic molecular trio in a two-step process, penetrating first the infected cells and then delivering bactericidal granzymes into the intracytoplasmic bacteria.

Copyright © 2014 Elsevier Inc. All rights reserved.

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