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J Cell Biochem. 2014 Oct;115(10):1808-15. doi: 10.1002/jcb.24851.

Protein kinase A regulates the osteogenic activity of Osterix.

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  • 1College of Pharmacy and Research Institute of Drug Development, Chonnam National University, Gwangju, Republic of Korea.

Abstract

Osterix belongs to the SP gene family and is a core transcription factor responsible for osteoblast differentiation and bone formation. Activation of protein kinase A (PKA), a serine/threonine kinase, is essential for controlling bone formation and BMP-induced osteoblast differentiation. However, the relationship between Osterix and PKA is still unclear. In this report, we investigated the precise role of the PKA pathway in regulating Osterix during osteoblast differentiation. We found that PKA increased the protein level of Osterix; PKA phosphorylated Osterix, increased protein stability, and enhanced the transcriptional activity of Osterix. These results suggest that Osterix is a novel target of PKA, and PKA modulates osteoblast differentiation partially through the regulation of Osterix.

© 2014 Wiley Periodicals, Inc.

KEYWORDS:

OSTEOBLAST DIFFERENTIATION; OSTERIX; PROTEIN KINASE A; PROTEIN STABILITY; TRANSCRIPTIONAL ACTIVITY

PMID:
24905700
[PubMed - indexed for MEDLINE]
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