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Dermatol Clin. 2014 Jul;32(3):315-34, viii. doi: 10.1016/j.det.2014.03.012.

Polymorphous light eruption: clinic aspects and pathogenesis.

Author information

  • 1Research Unit for Photodermatology, Department of Dermatology, Medical University of Graz, Auenbruggerplatz 8, Graz A-8036, Austria.
  • 2Cellular Photoimmunology Group, Infectious Diseases and Immunology, Department of Dermatology, Sydney Medical School, Royal Prince Alfred Hospital, The University of Sydney, 676, Blackburn Building D06, Darlington, New South Wales 2006, Australia.
  • 3Research Unit for Photodermatology, Department of Dermatology, Medical University of Graz, Auenbruggerplatz 8, Graz A-8036, Austria. Electronic address: peter.wolf@medunigraz.at.

Abstract

Polymorphous light eruption is an immunologically mediated photodermatosis with high prevalence, particularly among young women in temperate climates, characterized by pruritic skin lesions of variable morphology, occurring in spring or early summer on sun-exposed body sites. A resistance to ultraviolet radiation (UVR)-induced immunosuppression and a subsequent delayed-type hypersensitivity response to a photoantigen have been suggested as key factors in the disease. Molecular and immunologic disturbances associated with disease pathogenesis include a failure of skin infiltration by neutrophils and other regulatory immune cells on UVR exposure linked to a disturbed cytokine microenvironment. Standard management is based on prevention.

Copyright © 2014 Elsevier Inc. All rights reserved.

KEYWORDS:

Chemotaxis; Cytokines; Immune suppression; Photoantigen; Photoprotection; Polymorphic; Polymorphous light eruption; Skin cancer

PMID:
24891054
[PubMed - indexed for MEDLINE]
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