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Cell Biol Int. 2014 May 30. doi: 10.1002/cbin.10315. [Epub ahead of print]

Activation of protease-activated receptor-2 disrupts vaginal epithelial barrier function.

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  • 1Department of Obstetrics and Gynecology, Beijing Tongren Hospital, Capital Medical University, Beijing, China.

Abstract

The epithelial cell barrier function is a critical factor in the maintenance of the homeostasis of the vaginal mucosa. This study elucidates one of the mast cell-derived chemical mediators, tryptase, on compromising the vaginal epithelial barrier function. The results showed that human vaginal cell line, VK2, express PAR2. Activation of PAR2 increases the expression of ADAM10 in VK2 cells, interferes with the endosome/lysosome fusion, and compromises the epithelial barrier function. We conclude that the activation of PAR2 on VK2 cells increases the expression of ADAM10, and compromises the VK2 monolayer barrier function.

© 2014 International Federation for Cell Biology.

KEYWORDS:

barrier function; metalloproteinase domain-containing protein 10; protease-activated receptor 2; tryptase; vaginal epithelial cell

PMID:
24889831
[PubMed - as supplied by publisher]
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