Increased serum C1q-binding adiponectin complex to total-adiponectin ratio in men with multi-vessel coronary disease

Ken Kishida; Yasuhiko Nakagawa; Hironori Kobayashi; Koji Yanagi; Tohru Funahashi; Iichiro Shimomura

doi:10.1186/1758-5996-6-64

Increased serum C1q-binding adiponectin complex to total-adiponectin ratio in men with multi-vessel coronary disease

Diabetol Metab Syndr. 2014 May 27:6:64. doi: 10.1186/1758-5996-6-64. eCollection 2014.

Authors

Ken Kishida¹, Yasuhiko Nakagawa², Hironori Kobayashi³, Koji Yanagi⁴, Tohru Funahashi⁵, Iichiro Shimomura²

Affiliations

¹ Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan ; Kishida Clinic, Toyonaka, Osaka, Japan.
² Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan.
³ Department of Research and Development, Diagnostic Division, Otsuka Pharmaceutical Co., Ltd, Tokushima, Japan.
⁴ Department of Cardiology, Kenporen Osaka Central Hospital, Osaka, Japan.
⁵ Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan ; Department of Metabolism and Atherosclerosis, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan.

Abstract

Background: Adiponectin plays a role as a positive contributor to the stabilization of atherosclerotic plaques. Circulating total adiponectin (Total-APN) levels associates with the number of coronary vessels in men with coronary artery disease (CAD). We recently reported that adiponectin binds to C1q in human blood, and serum C1q-binding adiponectin (C1q-APN) /Total-APN levels are associated with CAD in type 2 diabetic subjects. The present study investigated the relationship between circulating C1q-APN levels and the number of angiographic coronary artery vessel in male subjects.

Methods: The study subjects were 53 male Japanese patients who underwent diagnostic coronary angiography. Blood total adiponectin (Total-APN), high-molecular weight adiponectin (HMW-APN), C1q-APN and C1q were measured by enzyme-linked immunosorbent assays.

Results: Serum C1q-APN/Total-APN ratio significantly increased in subjects with single and multi-vessel coronary diseases (p = 0.029 for trend, the Kruskal-Wallis test). However, serum Total-APN, HMW-APN, C1q-APN and C1q levels did not correlate with number of diseased coronary vessels.

Conclusion: Serum C1q-APN/Total-APN ratio progressively increases in men with single and multi-vessel coronary disease.

Trial registration: UMIN000002997.

Keywords: Adiponectin; Angiographic coronary vessel; C1q; C1q-binding adiponectin; Coronary artery disease.