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J Acquir Immune Defic Syndr. 2014 Sep 1;67(1):71-6. doi: 10.1097/QAI.0000000000000227.

Weight as predictors of clinical progression and treatment failure: results from the TREAT Asia Pediatric HIV Observational Database.

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  • 1*The Kirby Institute, Faculty of Medicine, University of New South Wales, Sydney, Australia; †TREAT Asia/amfAR-The Foundation for AIDS Research, Bangkok, Thailand; ‡Programs for HIV Prevention and Treatment, Institut de Recherche pour le Développement, France, and Chiang Mai University, Chiang Mai, Thailand; §YR Gaitonde Centre for AIDS Research and Education, Chennai, India; ‖Infectious Disease Department, Children's Hospital 2, Ho Chi Minh City, Vietnam; ¶Infectious Disease Department, National Hospital of Pediatrics, Hanoi, Vietnam; #Pediatric Department, Chiangrai Prachanukroh Hospital, Chiang Rai, Thailand; **Pediatric Department , Khon Kaen University, Khon Kaen, Thailand; ††Pediatric Department , Siriraj Hospital, Mahidol University, Bangkok, Thailand; ‡‡Infectious Disease Department, Children's Hospital 1, Ho Chi Minh City, Vietnam; §§Department of Pediatrics, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand; ‖‖TB/HIV Department, National Pediatric Hospital, Phnom Penh, Cambodia; ¶¶Research Unit, National Centre for HIV/AIDS, Dermatology and STDs, Phnom Penh, Cambodia; ##HIV-NAT/Thai Red Cross AIDS Research Centre, Bangkok, Thailand; ***Department of Pediatrics, Hospital Raja Perempuan Zainab II, Kelantan, Malaysia; †††Pediatric Allergy-Immunology Division, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; ‡‡‡Pediatric Institute, Hospital Kuala Lumpur, Kuala Lumpur, Malaysia; §§§Department of Pediatrics, Hospital Likas, Kota Kinabalu, Malaysia; ‖‖‖Department of Pediatrics, Penang Hospital, Penang, Malaysia; and ¶¶¶Allergy-Immunology Division, Sanglah Hospital, Udayana University, Bali, Indonesia.



To evaluate the value of time-updated weight and height in predicting clinical progression, and immunological and virological failure in children receiving combination antiretroviral therapy (cART).


We used Cox regression to analyze data of a cohort of Asian children.


A total of 2608 children were included; median age at cART was 5.7 years. Time-updated weight for age z score < -3 was associated with mortality (P < 0.001) independent of CD4% and < -2 was associated with immunological failure (P ≤ 0.03) independent of age at cART.


Weight monitoring provides useful data to inform clinical management of children on cART in resource-limited settings.

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