We experienced a case of hyperinfection with strongyloides stercoralis in a 64-year-old housewife who complained of severe epigastric pain associated with nausea, vomiting and general weakness for the period of one month. She received corticosteroid therapy for several months because of arthritis prior to admission. The diagnosis was confirmed by examination of gastroduodenal juice and gastrofiberoscopic biopsy. Stool examinations disclosed an abundance of the adult form of strongyloides stercoralis. Albendazole was given for treatment. The patient expired on the 79th hospital day.