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Biomed Res Int. 2014;2014:461034. doi: 10.1155/2014/461034. Epub 2014 Apr 17.

Does long-term use of silver nanoparticles have persistent inhibitory effect on H. pylori based on Mongolian gerbil's model?

Author information

  • 1Division of Gastroenterology, Department of Internal Medicine, Kaohsiung Medical University Hospital, 100 Tz-You 1st Road, Kaohsiung City 807, Taiwan ; Cancer Center, Kaohsiung Medical University Hospital, Kaohsiung City 807, Taiwan.
  • 2Division of Gastroenterology, Department of Internal Medicine, Kaohsiung Medical University Hospital, 100 Tz-You 1st Road, Kaohsiung City 807, Taiwan ; Department of Medicine, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, 100 Tz-You 1st Road, Kaohsiung City 807, Taiwan.
  • 3Department of Laboratory Medicine, Kaohsiung Medical University Hospital, Kaohsiung City 807, Taiwan.
  • 4Division of Gastroenterology, Department of Internal Medicine, Kaohsiung Medical University Hospital, 100 Tz-You 1st Road, Kaohsiung City 807, Taiwan.
  • 5Department of Medicine, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, 100 Tz-You 1st Road, Kaohsiung City 807, Taiwan ; Division of Infectious Diseases, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung City 807, Taiwan.
  • 6Department of Microbiology, Kaohsiung Medical University, Kaohsiung City 807, Taiwan.
  • 7School of Medicine, College of Medicine, E-Da Hospital, I-Shou University, Kaohsiung City 824, Taiwan.
  • 8Division of Gastroenterology, Department of Internal Medicine, Kaohsiung Medical University Hospital, 100 Tz-You 1st Road, Kaohsiung City 807, Taiwan ; Department of Medicine, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, 100 Tz-You 1st Road, Kaohsiung City 807, Taiwan ; Division of Internal Medicine, Kaohsiung Municipal Hsiao-Kang Hospital, Kaohsiung City 812, Taiwan.
  • 9Department of Life Sciences, National Chung Hsing University, 250, Kuo-Kuang Road, Taichung City 402, Taiwan.

Abstract

BACKGROUND:

It is urgent to find alternative agents due to increasing failure rate of Helicobacter pylori (H. pylori) eradication. The study surveyed the long-term effect of silver nanoparticles (AgNP) on H. pylori based on Mongolian gerbil's model.

MATERIALS AND METHODS:

Fifty gerbils were randomly allocated to six groups (A-F). Group (Gr) A: the gerbils were fed with broth; Gr B and D: the gerbils were fed with AgNP/clay complex (0.1% of weight); Gr C and E: the gerbils were fed with AgNP/clay complex(1% of weight); and Gr D, E, and F: the gerbils were inoculated with H. pylori. At the 20th experimental week, the gerbils were sacrificed. Histology was evaluated according to the classification of the Sydney system. P < 0.05 was considered to be statistically significant.

RESULTS:

The AgNP/clay has more obvious inhibitory effect on H. pylori in vitro. There was a trend of higher concentrations of AgNP with stronger inhibitory effect on H. pylori growth (P = 0.071). There were no significant differences of inflammation among groups D, E, and F (P = 0.688).

CONCLUSION:

AgNP/clay would be a potential and safe agent for inhibiting H. pylori. It should be helpful for eradication of H. pylori infection.

PMID:
24864246
[PubMed - indexed for MEDLINE]
PMCID:
PMC4016839
Free PMC Article
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