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J Pediatr Urol. 2014 Oct;10(5):969-73. doi: 10.1016/j.jpurol.2014.02.006. Epub 2014 Mar 15.

Feasibility of using CT volume as a predictor of specimen weight in a subgroup of patients with low risk Wilms tumors registered on COG Study AREN03B2: implications for central venous catheter placement.

Author information

  • 1Connecticut Children's Medical Center, University of Connecticut Medical School, 282 Washington Street, Hartford, CT 06106, USA. Electronic address:
  • 2Connecticut Children's Medical Center, University of Connecticut Medical School, 282 Washington Street, Hartford, CT 06106, USA. Electronic address:
  • 3IWK Health Center, Halifax, NS, Canada. Electronic address:
  • 4Washington University School of Medicine, St. Louis, MO, USA. Electronic address:
  • 5Children's National Medical Center, Washington, DC, USA. Electronic address:
  • 6Children's Oncology Group Statistics & Data Center, University of Florida, Gainesville, FL, USA. Electronic address:
  • 7Children's Hospital of Boston, Boston, MA, USA. Electronic address:
  • 8Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA. Electronic address:
  • 9Children's Hospital at Erlanger, Chattanooga, TN, USA. Electronic address:
  • 10Children's Hospital of Boston, Boston, MA, USA. Electronic address:
  • 11Mayo Clinic College of Medicine, Phoenix, AZ, USA. Electronic address:
  • 12University of Michigan Medical School, Ann Arbor, MI, USA. Electronic address:



Patients with stage I Wilms tumor, age ≤ 2 years, tumor ≤ 550 g may not require therapy beyond nephrectomy. This study's aims were to determine: (1) if a linear relationship exists between tumor weight and computed tomography (CT) estimated volume; (2) describe the accuracy of a slope-intercept equation in estimating weight; and (3) determine the potential impact of weight estimation on port placement decisions.


Tumor weight and port placement information were abstracted from 105 patients, age ≤ 2 years, with tumors ± 550 g, enrolled in COG AREN03B2. One radiologist estimated tumor size from CT scan. Prolate ellipse volume (PEV) was calculated, linear regression performed, slope-intercept equation calculated, equation estimated weight determined, and potential impact of the on port placement evaluated.


A strong relationship exists between PEV and weight (R(2) = 0.87). The slope-intercept equation for weight was: weight = 1.04(PEV) + 58.75. Overall median relative error for the equation was 0.9%, and -3% in tumors weighing 350-750 g. Fifty-five ports were placed, 29 in patients with tumor weight ≤ 550 g, and six not placed in patients with tumor weight > 550 g.


The relationship between PEV and weight produced a reliable weight prediction equation. Preoperative consideration of specimen weight may diminish the number of ports placed in this population.

Copyright © 2014 Journal of Pediatric Urology Company. Published by Elsevier Ltd. All rights reserved.


Central venous catheter; Computed tomography; Nephrectomy; Nephroblastoma; Wilms tumor

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[Available on 2015-10-01]
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