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Arq Neuropsiquiatr. 2014 May;72(5):337-43.

ENCOMS: Argentinian survey in cost of illness and unmet needs in multiple sclerosis.

Author information

  • 1Fleni, Buenos Aires, Argentina.
  • 2Instituto Neurociencias de Buenos Aires, Buenos Aires, Argentina.
  • 3Private Office, Buenos Aires, Argentina.
  • 4Hospital San Bernardo, Argentina.
  • 5Hospital Fernandez, Buenos Aires, Argentina.
  • 6SMYL, Argentina.
  • 7Centro Regional Integral de Neurociencia, Argentina.
  • 8Hospital Julio Mendez, Buenos Aires, Argentina.
  • 9Fundacion Favaloro, Buenos Aires, Argentina.
  • 10Instituto Argentino de Investigación Neurologica, Buenos Aires, Argentina.
  • 11Centro Neurologico Integral, Argentina.
  • 12Instituto de Neurociencias Cordoba, Cordoba, Argentina.
  • 13Hospital Italiano de Buenos Aires, Buenos Aires, Argentina.
  • 14Novartis, Argentina.
  • 15Novartis Latinoamerica & Canada, Argentina.


The objective of the study was to assess the cost of multiple sclerosis (MS) patients in Argentina categorized by disease severity using a societal perspective.


Cross-sectional study including MS patients from 21 MS centers in 12 cities of Argentina. Patients were stratified by disease severity using the expanded disability status scale (EDSS) (group 1 with EDSS score between 0 and 3; group 2 with EDSS >3 and <7; group 3 with EDSS ≥7). Direct and indirect costs were analyzed for the second quarter of 2012 from public sources and converted to US Dollars.


266 patients were included. Mean annual cost per MS patient was USD 36,025 (95%CI 31,985-38,068) for patients with an EDSS between 0-3; USD 40,705 (95%CI 37,199-46,300) for patients with EDSS >3 and <7, and USD 50,712 (95%CI 47,825-62,104) for patients with EDSS ≥7.


This is the first Argentine study evaluating the costs of MS considering disease severity.

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