Format

Send to:

Choose Destination
See comment in PubMed Commons below
Am J Med. 2014 Nov;127(11):1126.e13-25. doi: 10.1016/j.amjmed.2014.05.022. Epub 2014 May 23.

Syncope risk stratification tools vs clinical judgment: an individual patient data meta-analysis.

Author information

  • 1Medicina fisiopatologica, Dipartimento di Medicina Interna, Osp. L. Sacco, Milano, Italy. Electronic address: giorgic2@gmail.com.
  • 2Dipartimento di Scienze Biomediche e Cliniche "L. Sacco" - Universit√† degli Studi di Milano, Milano, Italy.
  • 3Emergency Medicine Research Group Edinburgh, Royal Infirmary of Edinburgh, UK.
  • 4Medicina fisiopatologica, Dipartimento di Medicina Interna, Osp. L. Sacco, Milano, Italy.
  • 5Department of Emergency Medicine, Oregon Health and Science University, Portland.
  • 6Electrophysiology Unit, Cardiology Division, Department of Medicine, Ospedale S. Giuseppe, Empoli, Italy.
  • 7Syncope Unit, Geriatric Cardiology and Medicine, Azienda Ospedaliero Universitaria Careggi and University of Florence, Firenze, Italy.
  • 8Department of Emergency Medicine, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, Mass.
  • 9Divisione di Cardiologia, Universit√† degli Studi di Torino, Torino, Italy.
  • 10Division of Emergency Medicine, Stanford University School of Medicine, Calif.
  • 11Division of Emergency Medicine, University of California, San Francisco.
  • 12Libin Cardiovascular Institute of Alberta, Calgary, Canada.
  • 13Internal Medicine, University of Milan, Humanitas Clinical and Research Center, Rozzano (MI), Italy.

Abstract

BACKGROUND:

There have been several attempts to derive syncope prediction tools to guide clinician decision-making. However, they have not been largely adopted, possibly because of their lack of sensitivity and specificity. We sought to externally validate the existing tools and to compare them with clinical judgment, using an individual patient data meta-analysis approach.

METHODS:

Electronic databases, bibliographies, and experts in the field were screened to find all prospective studies enrolling consecutive subjects presenting with syncope to the emergency department. Prediction tools and clinical judgment were applied to all patients in each dataset. Serious outcomes and death were considered separately during emergency department stay and at 10 and 30 days after presenting syncope. Pooled sensitivities, specificities, likelihood ratios, and diagnostic odds ratios, with 95% confidence intervals, were calculated.

RESULTS:

Thirteen potentially relevant papers were retrieved (11 authors). Six authors agreed to share individual patient data. In total, 3681 patients were included. Three prediction tools (Osservatorio Epidemiologico sulla Sincope del Lazio [OESIL], San Francisco Syncope Rule [SFSR], Evaluation of Guidelines in Syncope Study [EGSYS]) could be assessed by the available datasets. None of the evaluated prediction tools performed better than clinical judgment in identifying serious outcomes during emergency department stay, and at 10 and 30 days after syncope.

CONCLUSIONS:

Despite the use of an individual patient data approach to reduce heterogeneity among studies, a large variability was still present. Current prediction tools did not show better sensitivity, specificity, or prognostic yield compared with clinical judgment in predicting short-term serious outcome after syncope. Our systematic review strengthens the evidence that current prediction tools should not be strictly used in clinical practice.

Copyright © 2014 Elsevier Inc. All rights reserved.

KEYWORDS:

Individual patient data; Meta-analysis; Prognosis; Risk-stratification tools; Rules; Syncope

PMID:
24862309
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk