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Cancer Radiother. 2014 Jul-Aug;18(4):264-9. doi: 10.1016/j.canrad.2014.04.003. Epub 2014 May 24.

[Radiobiology of ablative dose in stereotactic irradiation: data update].

[Article in French]

Author information

  • 1Département universitaire de radiothérapie, centre de lutte contre le cancer Paul-Strauss, 3, rue de la Porte-de-l'Hôpital, BP 42, 67065 Strasbourg cedex, France; EA 3430, laboratoire de radiobiologie, centre Paul-Strauss, université de Strasbourg, 3, rue de la Porte-de-l'Hôpital, BP 42, 67065 Strasbourg, France.
  • 2EA 3430, laboratoire de radiobiologie, centre Paul-Strauss, université de Strasbourg, 3, rue de la Porte-de-l'Hôpital, BP 42, 67065 Strasbourg, France.
  • 3Département universitaire de radiothérapie, centre de lutte contre le cancer Paul-Strauss, 3, rue de la Porte-de-l'Hôpital, BP 42, 67065 Strasbourg cedex, France; EA 3430, laboratoire de radiobiologie, centre Paul-Strauss, université de Strasbourg, 3, rue de la Porte-de-l'Hôpital, BP 42, 67065 Strasbourg, France. Electronic address: gnoel@strasbourg.unicancer.fr.
  • 4Département de radiothérapie oncologique, centre hospitalier Lyon-Sud, 165, chemin du Grand-Revoyet, 69310 Pierre-Bénite-Lyon, France; EA 3738, université Claude-Bernard - Lyon-1, domaine Rockefeller, 8, avenue Rockefeller, 69373 Lyon cedex 08, France.

Abstract

Stereotactic radiotherapy is a radiation technique, which is becoming more and more available and applicable for physicians. A good efficacy and safety are observed in clinical practice. However, the radiobiology of ablative radiation is still under question. The radiobiological principles of the 5R have to be discussed. The roles of hypoxia and vascularization, more specifically, angiogenesis and vasculogenesis seem to be dominating.

Copyright © 2014 Société française de radiothérapie oncologique (SFRO). Published by Elsevier SAS. All rights reserved.

KEYWORDS:

Ablative dose; Angiogenesis; Angiogenèse; Dose ablative; Hypoxia; Hypoxie; Radiobiologie; Radiobiology; Stereotactic; Stéréotaxie; Vasculogenesis; Vasculogenèse

PMID:
24860988
[PubMed - indexed for MEDLINE]
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