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Int J Pharm. 2014 Aug 25;471(1-2):166-72. doi: 10.1016/j.ijpharm.2014.05.028. Epub 2014 May 22.

Multimeric grain-marked micelles for highly efficient photodynamic therapy and magnetic resonance imaging of tumors.

Author information

  • 1Department of Biotechnology, The Catholic University of Korea, 43-1 Yeokgok 2-dong, Wonmi-gu, Bucheon-si, Gyeonggi-do 420-743, Republic of Korea.
  • 2Department of Radiology, Severance Hospital, Yonsei University College of Medicine, 134 Shinchon-dong, Seodaemun-gu, Seoul 120-752, Republic of Korea.
  • 3Department of Biomedical Engineering, Yale University, 55 Prospect Street, 401 Malone Engineering Center, New Haven, CT 06511, USA.
  • 4Department of Biotechnology, The Catholic University of Korea, 43-1 Yeokgok 2-dong, Wonmi-gu, Bucheon-si, Gyeonggi-do 420-743, Republic of Korea. Electronic address: eslee@catholic.ac.kr.

Abstract

Multimeric grain-marked micelles consisting of an inner core micelle (for Fe3O4 encapsulation) and outer multi-grain micelles (for chlorin e6 (Ce6, a model drug) encapsulation) were fabricated using a micelle-to-micelle conjugation method. Grain micelles (mono-thiol functionalized micelles) were chemically linked to the surface of the core micelle (multi-maleimide functionalized micelle). These micelles enable discrete compartments for Ce6 and iron oxide (Fe3O4) that enable a significantly increased in vivo photodynamic tumor inhibition while preserving high contrast magnetic resonance (MR) imaging of the tumor in vivo.

Copyright © 2014 Elsevier B.V. All rights reserved.

KEYWORDS:

Chlorin e6 (Ce6); Grain-marked micelles; Magnetic resonance imaging; Multimeric micelles; Photodynamic therapy

PMID:
24858385
[PubMed - in process]
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