Targeting the homologous recombination pathway by small molecule modulators

Fei Huang; Alexander V Mazin

doi:10.1016/j.bmcl.2014.04.088

Targeting the homologous recombination pathway by small molecule modulators

Bioorg Med Chem Lett. 2014 Jul 15;24(14):3006-13. doi: 10.1016/j.bmcl.2014.04.088. Epub 2014 May 6.

Authors

Fei Huang¹, Alexander V Mazin²

Affiliations

¹ Department of Biochemistry and Molecular Biology, Drexel University College of Medicine, Philadelphia, PA 19102-1192, United States.
² Department of Biochemistry and Molecular Biology, Drexel University College of Medicine, Philadelphia, PA 19102-1192, United States. Electronic address: amazin@drexelmed.edu.

Abstract

During the last decade, the use of small molecule (MW <500 Da) compounds that modulate (inhibit or activate) important proteins of different biological pathways became widespread. Recently, the homologous recombination (HR) pathway emerged as a target for such modulators. Development of small molecule modulators pursues two distinct but not mutually exclusive purposes: to create a research tool to study the activities or functions of proteins of interest and to produce drugs targeting specific pathologies. Here, we review the progress of small molecule development in the area of HR.

Keywords: BLM; DNA double stranded breaks; DNA repair; RAD51; RAD54; WRN.

Publication types

Research Support, N.I.H., Extramural
Review

MeSH terms

Animals
Homologous Recombination / drug effects*
Humans
Small Molecule Libraries / chemical synthesis
Small Molecule Libraries / chemistry
Small Molecule Libraries / pharmacology*

Substances

Small Molecule Libraries

Abstract

Publication types

MeSH terms

Substances

Grants and funding